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Introduction to 3-CMC

 buy 3cmc (3-Chloromethcathinone), also known as clophedrone, is a synthetic cathinone belonging to the substituted cathinone class of compounds. It is the chlorinated analogue of methcathinone, distinguished by the substitution of a chlorine atom at the 3-position of the phenyl ring . The compound has been identified as a new psychoactive substance (NPS) and has been circulating in the European market since at least 2014 .

Following a risk assessment by the EMCDDA in November 2021, the European Commission adopted measures to control 3-CMC across the EU . At the time of assessment, 3-CMC had been detected in 23 Member States, with two Member States reporting a total of 10 deaths with confirmed exposure to the substance . More recent data shows that 3-CMC accounted for over 63% of all NPS seized in Europe in 2024, highlighting its growing significance in forensic casework.

As a research chemical, 3-CMC is primarily utilized as a certified reference material for forensic and analytical applications, including GC-MS and LC-MS method development. At 4mmcchems, we supply premium-grade 3-CMC reference materials to researchers and professionals worldwide, with a focus on fast, discreet shipping across Europe.

Product Specifications

Product Name: 3-CMC (3-Chloromethcathinone)

Synonyms: Clophedrone, 3-chloroephedrone, 1-(3-chlorophenyl)-2-(methylamino)propan-1-one

CAS Number: 1607439-32-6 (hydrochloride salt)

Molecular Formula: C₁₀H₁₂ClNO

Molecular Weight: 197.66 g/mol (free base); 234.12 g/mol (HCl salt)

Purity: ≥ 98% (verified by third-party HPLC/GC-MS testing)

Form: Crystalline solid; neat solid format available

Storage: -20°C for long-term stability

Availability: In stock, ready for immediate dispatch

Chemical Properties and Mechanism of Action

3-CMC belongs to the synthetic cathinone family, which are derivatives of the naturally occurring stimulant cathinone found in the khat plant. As a substituted cathinone, it acts as a monoamine transporter modulator, affecting dopamine, serotonin, and norepinephrine signaling in research models.

Key Pharmacological Data

• Mechanism: Non-selective monoamine releaser, acting at dopamine and serotonin transporters

• Structural Class: Substituted cathinone (chlorinated methcathinone analogue)

• Potency Comparison: 3-CMC demonstrates greater potency at the dopamine transporter (DAT) and less potency at the serotonin transporter (SERT) compared to its positional isomer 4-CMC

• International Status: The WHO Expert Committee on Drug Dependence has recommended that 3-CMC be added to Schedule II of the Convention on Psychotropic Substances of 1971

Analytical Applications

3-CMC is a recognized forensic reference material. It is included in GA/T 1925-2021, the Chinese public safety industry standard for the GC-MS and GC analysis of cathinone compounds in suspected drug samples . Certified reference solutions are available at concentrations of 1 mg/mL in methanol for analytical method development .

Why Choose 4mmcchems?

1. Uncompromising Quality

We source our 3-CMC reference materials from certified manufacturers with strict adherence to Good Manufacturing Practice (GMP) guidelines. Every batch undergoes independent HPLC and GC-MS testing to guarantee purity and potency, meeting the ≥98% purity threshold expected for analytical reference standards . Certified reference materials are available with validated purity specifications for reliable forensic and analytical applications.

2. Discreet and Secure Packaging

Your privacy is paramount. All orders are shipped in plain, unbranded packaging with no external markings indicating contents. Tamper-evident seals ensure security throughout transit.

3. Worldwide Shipping with European Focus

4mmcchems operates a robust global logistics network. We offer fast, reliable shipping to customers worldwide, with a particular emphasis on European markets:

• European Shipping: 3-CMC has been identified in 23 EU Member States, as well as Turkey and Norway . We have optimized shipping routes to ensure timely delivery across the continent, including Germany, France, the United Kingdom, Spain, Italy, the Netherlands, Switzerland, and more.

• Fast Transit Times: Typical delivery to European destinations ranges from 3 to 7 business days.

• Tracking Provided: Every order comes with a tracking number for real-time shipment monitoring.

4. Competitive Pricing and Bulk Discounts

We offer tiered pricing for bulk orders, making 4mmcchems the cost-effective choice for large-scale research projects. Contact our sales team for custom quotes.

5. Responsive Customer Support

Our knowledgeable team is available to answer queries regarding product specifications, shipping, and order status. We prioritize clear and prompt communication.

Safety and Regulatory Information

3-CMC is subject to regulatory control in multiple jurisdictions. As a chlorinated cathinone analogue, it has been associated with documented cases of acute poisoning and fatalities . Available information suggests that consumption of 3-CMC causes harm to health due to its high toxicity, with these health damages considered potentially life-threatening .

European Regulatory Status

3-CMC has been included in the definition of “drug” under Framework Decision 2004/757/JHA by Commission Delegated Directive (EU) 2022/1326 . EU Member States were required to implement measures to prohibit the production, manufacture, extraction, preparation, offering, sale, distribution, transport, import, and export of 3-CMC by 18 February 2023 .

A total of 13 Member States control 3-CMC under national drug control legislation, seven under new psychoactive substances legislation, and one under other legislation . The Netherlands placed 3-CMC on List I of the Opium Act, classifying it as a hard drug .

In Poland, recent enforcement actions have targeted large-scale 3-CMC production operations, with over 500 kg of chemical substances seized in December 2025 and additional arrests made in 2026 .

Important Considerations for Researchers:

• Controlled Status: 3-CMC is a controlled substance in many countries and is subject to EU-wide control measures. It is the customer’s responsibility to verify the legal status of this product in their jurisdiction before placing an order .

• Research Use Only: This product is intended for research, forensic, and analytical applications only. Not for human or veterinary use. 3-CMC has no recognized therapeutic use .

• Handling Precautions: Standard laboratory safety protocols should be followed when handling this compound. Certified reference materials should be stored at -20°C for long-term stability .

Shipping Information: Worldwide Delivery

4mmcchems is committed to making our products accessible globally. We ship to all major regions, including:

• Europe: All EU member states, UK, Switzerland, Norway, and more.

• North America: USA, Canada, Mexico.

• Asia: Japan, South Korea, Singapore, China, India, and others.

• Australia & Oceania

• South America

• Middle East & Africa

Shipping Methods:

• Standard Air Mail (7-21 days, tracking available)

• Express Courier (3-7 days, fully tracked, signature required)

Customs and Duties: Customers are responsible for any customs duties or import taxes applicable in their country. We provide all necessary documentation to facilitate smooth customs clearance, subject to local regulations. Note that 3-CMC precursors are subject to EU-wide control under Delegated Regulation (EU) 2026/314, which introduces stricter licensing and traceability requirements for legitimate trade .

How to Order

1. Browse Our Catalog: Select 3-CMC and add to cart.

2. Checkout: Fill in your shipping details and choose your preferred payment method.

3. Payment: We accept cryptocurrencies and bank transfers for secure transactions.

4. Confirmation: Receive an order confirmation with tracking details upon dispatch.

Frequently Asked Questions

Q: What is 3-CMC used for in research?

A: 3-CMC is used as an analytical reference material for forensic and toxicological applications, including GC-MS and LC-MS testing for the identification and quantification of synthetic cathinones in suspected drug samples and biological matrices .

Q: Is 3-CMC legal to purchase?

A: 3-CMC is controlled in many countries, particularly across Europe where it has been identified in 23 Member States. It is the customer’s responsibility to verify the legal status of this product in their jurisdiction before placing an order .

Q: How should 3-CMC be stored?

A: Store at -20°C for long-term stability. Protect from light and moisture .

Q: What if my order is seized by customs?

A: While we take every precaution to ensure successful delivery, we cannot guarantee customs clearance in all countries, especially given the strict controls on 3-CMC. Please refer to our shipping policy for more details.