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Introduction to A-PiHP Crystals.

A-PiHP (alpha-Pyrrolidinoisohexanophenone), also known as 4-methyl-1-phenyl-2-(pyrrolidin-1-yl)pentan-1-one, is a synthetic cathinone belonging to the pyrovalerone class of compounds . It is a structural isomer of alpha-PHP, distinguished by a methyl group substitution at the 4-position of the pentyl chain .

Within the research community, A-PiHP is primarily utilized in neuropharmacological studies investigating monoamine transporter interactions, forensic analytical applications, and as a reference standard for identifying novel psychoactive substances . At ForeverChems, we supply premium-grade A-PiHP Crystals to researchers and professionals worldwide, with a focus on fast, discreet shipping across Europe.

Product Specifications

Product Name: A-PiHP Crystals (alpha-Pyrrolidinoisohexanophenone)

CAS Number: 2705245-60-7 (hydrochloride salt) 

Molecular Formula: C₁₆H₂₃NO · HCl 

Molecular Weight: 281.82 g/mol (hydrochloride salt)

Purity: ≥ 98% (verified by third-party HPLC testing) 

Form: Crystalline solid 

Storage: -20°C for long-term stability 

Availability: In stock, ready for immediate dispatch

Chemical Properties and Mechanism of Action

A-PiHP belongs to the pyrovalerone-type synthetic cathinones, a subclass characterized by an extended alpha-carbon sidechain and a pyrrolidine ring . In vitro characterization has demonstrated that these compounds predominantly act as potent dopamine transporter (DAT) and norepinephrine transporter (NET) inhibitors, unlike other synthetic cathinones that function as substrate releasers .

Key Pharmacological Data

Research has established the potent activity of A-PiHP and its analogues at monoamine transporters:

• DAT inhibition (IC₅₀): 0.5–7.6 nM for methyl-substituted analogues, with 4-Me-alpha-PiHP showing the highest potency at 0.5 nM 

• NET inhibition: Moderate potency (163–197 nM) 

• SERT inhibition: Weak activity (>900 nM), demonstrating high selectivity for DAT over SERT 

• DAT/SERT ratio: Surpasses cocaine’s ratio by more than 40-fold, indicating a stimulant-like profile and elevated reinforcing potential 

In vivo self-administration studies in animal models have shown strong reinforcing potentials for pyrovalerone-type cathinones, in some cases surpassing the reinforcing potentials of cocaine . Molecular docking studies indicate that these compounds interact with the orthosteric binding site at hDAT and display higher binding affinity than cocaine .

Why Choose ForeverChems?

1. Uncompromising Quality

We source our A-PiHP Crystals from certified manufacturers with strict adherence to Good Manufacturing Practice (GMP) guidelines. Every batch undergoes independent HPLC and mass spectrometry testing to guarantee purity and potency. The crystalline form provides a uniform molecular profile and superior stability for laboratory applications .

2. Discreet and Secure Packaging

Your privacy is paramount. All orders are shipped in plain, unbranded packaging with no external markings indicating contents. Tamper-evident seals and specialized airtight containers ensure security and chemical integrity throughout transit .

3. Worldwide Shipping with European Focus

ForeverChems operates a robust global logistics network. We offer fast, reliable shipping to customers worldwide, with a particular emphasis on European markets:

• European Shipping: We have optimized shipping routes to ensure timely delivery to countries including Germany, France, the United Kingdom, Spain, Italy, the Netherlands, Switzerland, and more. A-PiHP has been detected in 18 EU member states and is controlled in at least seven .

• Fast Transit Times: Typical delivery to European destinations ranges from 3 to 7 business days.

• Tracking Provided: Every order comes with a tracking number for real-time shipment monitoring .

4. Competitive Pricing and Bulk Discounts

We offer tiered pricing for bulk orders, making ForeverChems the cost-effective choice for large-scale research projects. Contact our sales team for custom quotes.

5. Responsive Customer Support

Our knowledgeable team is available to answer queries regarding product specifications, shipping, and order status. We prioritize clear and prompt communication.

Safety and Regulatory Information

A-PiHP is classified as a regulated substance in many jurisdictions. According to the World Health Organization’s Expert Committee on Drug Dependence, A-PiHP has no known therapeutic use and has not received marketing authorization as a medication . The compound is associated with serious adverse events, including reported fatalities .

As of 2023, the WHO has recommended placing A-PiHP in Schedule II of the 1971 Convention on Psychotropic Substances .

Important Considerations for Researchers:

• Controlled Status: A-PiHP is a controlled substance in many countries. It is the customer’s responsibility to verify the legal status of this product in their jurisdiction before placing an order.

• Research Use Only: This product is intended for research, forensic, and analytical applications only. Not for human or veterinary use .

• Handling Precautions: Standard laboratory safety protocols should be followed when handling this compound.

Shipping Information: Worldwide Delivery

ForeverChems is committed to making our products accessible globally. We ship to all major regions, including:

• Europe: All EU member states, UK, Switzerland, Norway, and more.

• North America: USA, Canada, Mexico.

• Asia: Japan, South Korea, Singapore, China, India, and others.

• Australia & Oceania

• South America

• Middle East & Africa

Shipping Methods:

• Standard Air Mail (7-21 days, tracking available)

• Express Courier (3-7 days, fully tracked, signature required)

Customs and Duties: Customers are responsible for any customs duties or import taxes applicable in their country. We provide all necessary documentation to facilitate smooth customs clearance.

How to Order

1. Browse Our Catalog: Select A-PiHP Crystals and add to cart.

2. Checkout: Fill in your shipping details and choose your preferred payment method.

3. Payment: We accept cryptocurrencies and bank transfers for secure transactions.

4. Confirmation: Receive an order confirmation with tracking details upon dispatch.

Frequently Asked Questions

Q: What is A-PiHP used for?

A: A-PiHP is used as an analytical reference material for research and forensic applications, including transporter binding assays and neuropharmacological studies .

Q: Is A-PiHP legal to purchase?

A: A-PiHP is a controlled substance in many countries. It is the customer’s responsibility to verify the legal status of this product in their jurisdiction before placing an order .

Q: How should A-PiHP be stored?

A: Store in a cool, dry place away from light and moisture. Long-term storage at -20°C is recommended for optimal stability .

Q: What if my order is seized by customs?

A: While we take every precaution to ensure successful delivery, we cannot guarantee customs clearance in all countries. Please refer to our shipping policy for more details.

  A-PiHP crystal meets the demands of cutting-edge studies in neuropharmacology, toxicology, and forensic science. With its emergence as a key compound in the cathinone family since 2016, alpha-PiHP has become essential for investigating novel psychoactive substances (NPS) and their impacts on monoamine systems.